England international Zamora, who played under Hughes at Fulham, joined Rangers on transfer deadline day and will make his debut in Saturday's clash with Wolves.
The 31-year-old will play alongside former Liverpool and Sunderland striker Cisse, who scored on his debut in Wednesday's 2-2 draw with Aston Villa.
Rangers are currently two places and three points above the relegation zone but, following a busy transfer window at Loftus Road, Hughes is looking up the table rather than down.
"I'm really looking forward to seeing them play together, they've got great qualities that will complement each other," Hughes said.
"I think Bobby enjoyed his time under me at Fulham. The type of work we gave him helped him and we supported him when he was out through injury.
"When he came back in the second half of last season he was exceptional and was a big reason why we ended up eighth in the Premier League.
"If he can have a similar impact in the second half of this season that will augur well for us because we need to win games and score goals, that's why he is here."
Cisse, 30, is back in England after spells with Panathinaikos and Lazio and took just 12 minutes to get off the mark for his new club at Villa Park.
Hughes added: "Djibril's style of play is made to measure for the Premier League. In Italy the style of play was too slow, he's very much a Premier League player in my opinion.
"If you look at his goalscoring record he has played just over 450 games and scored 220 goals, at top clubs, and not many strikers have that goals-to-game ratio.
"That's what got me excited about bringing him here. He's fitted in extremely well and he's glad to be back in the Premier League.
"We have invested heavily but what I wanted was complementary skills and different skill sets within the group of strikers I have available and we've got that now.
"I'm very comfortable with the work we did in the window and the quality of strikers is now very good."
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