Top-scorer Charlie Austin's strike and a Jean-Yves M'voto own goal gave the away side a half-time lead, while a brilliant solo effort from Yun Suk-Young capped the victory after the break.
Barnsley fought hard, and twice fought back to within a goal with Chris O'Grady efforts, but too often did not have the quality to go with their work rate in this Sky Bet Championship contest.
Both teams made a host of changes. With most of Barnsley's loan players returning this week the hosts made five, while QPR - with one eye on their forthcoming play-off campaign - fielded seven changes.
Bond explained: "I always felt once we took the lead that we'd hold them off. You never like to concede goals but we had a much-changed side than we normally play.
"We needed to have one eye on whoever we're going to play next Friday in the play-offs, so we did what we thought was the right thing.
"We want to bounce straight back up, desperately. We're going to have Wigan and it's going to be a very difficult game. They're looking to bounce back like we are so I would expect a really tight contest.
"We had a particularly good first half of the season, but we have never been a prolific goalscoring team. I don't think anything's gone wrong even though people might have an opinion on what they perceive we should be doing this season.
"If we can get ourselves promoted this season in any way, shape or form, I think it would be an amazing achievement."
Barnsley manager Danny Wilson was surprised to see his team trailing at the break, and is already looking to build towards next season in League One. He said: "I was a little bit confused at half time, being 2-0 down. I thought up until then we'd done very well.
"We were playing against a top-quality team and you're going to have parts of the game where you lose possession to them, but we held our own very well.
"It's bound to be a much-changed side in August. Chris O'Grady is bound to attract interest, he's scored 15 goals in a team that's struggled, but we want to do the best we can do for us.
"It's one of the biggest overhauls I've had to do in my career. It'll be tough to get the players in that we want, but I'd like to think that in League One we're a bit of a draw. The infrastructure and the set-up here is conducive to getting some quality players in."