The Royals host Fulham having claimed only three points from seven matches while throwing away leads against both Swansea and Newcastle.
McDermott accepts it has been a difficult start to life back in the top flight, but he is confident he can revive the club's fortunes with the backing of the supporters.
"We really need the fans. They have to believe," McDermott said. "They have been important to us since I became manager.
"They have stuck by us when times have been difficult. Now we are going through a difficult spell of results but they can really pull us through.
"Everyone knows the Madejski Stadium is a very difficult place to come and get a result and the fans are a big part of that. I'm sure they do believe that we can do whatever we have to do in this league."
Reading striker Jason Roberts, who will again shun the wearing of a Kick It Out campaign t-shirt, also insisted his side have not been rewarded for some encouraging displays.
"The performances have been better than the results, but that's the Premier League for you," he said. "As a group we are new to this league, but we have a strong squad.
"We are disappointed with the results but we believe that will change. We believe in each other's ability and we have a good chance of turning things around. That first win is on its way."