Gokhan Inler cancelled out an early Giorgio Chiellini goal to earn Napoli a 1-1 draw against Juventus in a top-of-the-table clash at the Stadio San Paolo on Friday night.
Juve appeared to be on course for a nine-point cushion at the top of the table when Chiellini headed them in front in the 10th minute, while they scuppered further chances to increase their lead.
Napoli then levelled just before half-time with a deflected effort and had the better chances to win the game in the second half, but ultimately had to settle for a point which maintains the six-point gap between the two sides.
AC Milan climbed above Lazio into third place with a comfortable 3-0 win over the Biancoceleste at the San Siro on Saturday.
Giampaolo Pazzini was on target twice for the Rossoneri, who played over 70 minutes with an extra man following a red card to Antonio Candreva.
Kevin-Prince Boateng also found the back of the net as Milan moved a point above their opponents and into a qualifying berth for the Champions League next season.
On Sunday, Rodrigo Palacio scored twice from the bench as Inter Milan completed an impressive comeback victory at Catania.
With the Sicilians pushing hard for a Europa League place, Andrea Stramaccioni's men appeared all too happy to oblige their hosts as Catania took a two-goal lead through Gonzalo Bergessio and Giovanni Marchese.
That prompted a desperate reshuffle and a gritty Inter side steadily forced their way back into the game as Palacio followed up Ricky Alvarez's 52nd-minute header.
Inter were not prepared to concede fifth place to Fiorentina, who beat Chievo 2-1, and Palacio struck at the end to snatch the three points for Inter.
Substitute Marcelo Larrondo headed a late winner at the Stadio Artemio Franchi to boost Fiorentina's Champions League hopes.
La Viola, who went down 2-1 at Bologna on Tuesday, started on the front foot and took an early lead through Manuel Pasqual's fine free-kick.
Chievo substitute Isaac Cofie got the visitors back on level terms seven minutes before half-time, but Larrondo - a 65th-minute replacement for Stevan Jovetic - had the last word with the decisive goal 12 minutes from time.
Roma's Francesco Totti made Serie A history as his first-half penalty in a 3-1 victory over 10-man Genoa saw the veteran striker become the league's joint-second highest scorer of all time.
The 36-year-old needed one more goal to match former AC Milan striker Gunnar Nordahl's career haul of 225 goals, and that goal arrived from the penalty spot with 15 minutes on the clock.
Genoa battled hard to spoil Totti's night, though, and Marco Borriello ensured the second half would be a contest by converting a spot-kick of his own, against his former club, just before the break.
Teenage defender Alessandro Romagnoli then took his first step towards chasing Totti's goal record with his maiden league goal and Simone Perrotta put the result beyond doubt after Juraj Kucka was dismissed following an angry exchange with Totti.
Sampdoria climbed into the top half and above opponents Parma as Mauro Icardi scored the only goal in a 1-0 victory at the Stadio Luigi Ferraris.
The Gialloblu were left to rue the officials' decision to disallow Andrea Coda's first-half goal but Roberto Donadoni's men were always second best as they drifted towards a fifth defeat in six games.
Samp had been concerned with Icardi's lack of goals in recent weeks but the Argentinian ended his two-game drought by converting an easy finish following a poor mistake from Parma goalkeeper Antonio Mirante.
Bologna took a significant step towards securing their future in Serie A by ending Cagliari's seven-game unbeaten run with a 3-0 win at the Renato Dall'Ara.
Saphir Taider's early opener helped earn Stefano Pioli's men back-to-back victories for the first time this season, following Tuesday's win over Fiorentina, with Alessandro Diamanti making the points safe midway through the second half.
Francesco Pisano's red card followed a careless tackle and saw the Sardinians reduced to 10 men before substitute Cristian Pasquato added gloss to the scoreline as Bologna opened an 11-point gap on the bottom three.
Giacomo Bonaventura scored in either half to move Atalanta nine points clear of the drop zone with a 2-0 victory over Siena.
Bonaventura opened the scoring with a cracking strike in the opening minutes and sealed the win midway through the second half with another fine effort.
Siena remain in the final relegation spot, five points adrift of safety.
Pescara's recent woes continued after Antonio Di Natale's 150th Serie A goal was enough to earn the three points for Udinese.
Serie A's second-bottom club headed into the encounter at the Stadio Adriatico-Giovanni Cornacchia in awful form after losing six of their last seven matches and, sadly for them, that poor form continued.
Palermo's struggles continue after they picked up only a point from their trip to Torino, who had the better chances in a 0-0 draw at the Stadio Olimpico.
Rolando Bianchi hit the post early on before two late chances were wasted as the Granata were denied victory in front of their own fans.
Gian Piero Gasperini's return to the Palermo bench ended with a point which lifts them into a three-way tie for bottom spot, still five points adrift of safety with games running out for the Rosaneri.