Referee Mark Clattenburg waved away two Southampton penalty appeals in the 2-1 defeat at Everton on Sunday, leaving Pochettino fuming ahead of their New Year's Day clash with Chelsea on the south coast.
"These things need to be said and I am actually defending my club because it is my club and I think if I don't talk I am going to seem as if I am dumb or I don't care about my club," he said.
"I don't mean any disrespect against any referees but anyone that could have seen the game on Sunday can see there were two clear penalties that weren't given and should have been given.
"That would have changed the game completely but they weren't given and of course we are angry and upset about that.
"I am saying things that should not be forgotten in the overall analysis of the game and they need to be said.
"I don't mean any disrespect to anyone but there were two clear penalties that weren't given and that's very frustrating."
Asked if referees are more likely to give decisions to big-name teams and players who will complain to them, he added: "That is the case and it shouldn't be that way. They shouldn't be conditioned to referee in that manner but that is the way it is."