Pochettino is unbeaten against City in the two games he has faced them as Southampton boss, leading his team to a win and a draw against the big spenders.
Manuel Pellegrini's side are still in the title hunt but Pochettino is convinced they can deal a blow to their aspirations of reclaiming the Premier League crown they last won in 2011/12.
"We always have the belief that we are going to win," he said.
"We know we are going to be facing a very tough side in Manchester City, a side that is definitely a candidate to win in the Premier League and are one of the best teams in England and Europe.
"Despite that we are still going with the belief that we are going to play our game and we are going to get something out of that game.
"We are going there with a clear idea to play our game, to play our style, and also to try to maintain if we can maintain the high standards that we showed (in a 4-0 victory) against Newcastle.
"We are going with the mentality to play a very good game against a very tough side."