The 25-year-old has been linked with a transfer to Anfield throughout the summer and looks likely to complete a £20million switch in the coming days.
Southampton paid Lyon £8.5m for the Croatia international 13 months ago and he had an impressive first season at St Mary’s.
Lovren’s exit will mean Saints have lost three key players from last season as well as manager Mauricio Pochettino.
Asked if he anticipates Lovren’s exit, Southampton boss Ronald Koeman said: “I expect everything.
“Because I know Southampton, I know the possibilities of the biggest club in England, and they had a great season, and it’s normal that you will lose some players.”
Adam Lallana and Rickie Lambert are already at Liverpool, while defender Luke Shaw sealed a move to Manchester United.
Southampton have already received over £50m on those sales, and could be about to take in even more cash with the sales of Lovren and Morgan Schneiderlin.
The French midfielder could be about to link up with former boss Pochettino at Tottenham in the next week.
Tottenham’s bitter rivals Arsenal are also interested in the player, who cost Southampton £1.2m when he arrived from Strasbourg in June 2008.
@GVMUFC, I agree, I think either a 4-5-1 or a 4-3-3 will be the formations/systems Rodgers will play with this season. Yeah the defenders aren't too bad at all, what cost us was defensive cover in midfield so Can has looked good in pre-season so I am hoping he will step in and be the box to box midfielder we need and shield the back 4. I have a feeling Gerrard's role this season will be greatly diminished which makes sense as he will be nearly 35 by the end of the season. We still need a new striker though as Sturridge will get injured at some stage and Lambert/Borini aren't good enough to keep us in the top 4. Rumours are that we are after Shaqiri for 14-17m who I think could play as a striker.- lfcfan80