Teenage right-back Calum Chambers became the latest starlet to leave the south coast club on Monday - signing for Arsenal for a rumoured £16m and joining the likes of Adam Lallana, Luke Shaw and Rickie Lambert in waving goodbye to Southampton this summer.
Rumours abound that former Saints manager Mauricio Pochettino will also attempt to lure midfielder Morgan Schneiderlin and striker Jay Rodriguez to his new club Tottenham, but Reed is adamant the Academy conveyor belt can continue to plug the holes left by big-money sales.
He told the club's official website: "Our position remains unchanged in that we are determined to keep our best young players at the club, as is evidenced by the decision to award Harrison Reed a new long-term contract last week,
"He adds to the list of committed young professionals like James Ward Prowse, Sam Gallagher, Jack Stephens, Jordan Turnbull, Matt Targett, Sam McQueen and others who have seen plenty of first-team activity recently.
"We have an abundance of talent in the academy coming through, and everybody at the club is continuing to work hard on bringing in quality new players as we build a team capable of taking us further forward in the coming seasons.
"It is important in the transfer window to remain calm, resilient and above all patient. We have targets, and we are working hard to get them across the line."
New Saints boss Ronald Koeman published a picture of an empty training ground on Monday - a tweet some interpreted as criticism of the board's transfer policy.