Shawcross has been unwell and did not train on Thursday, and while Hughes is hopeful the defender will recover, he needs to be sure.
"Ryan Shawcross has been ill all this week," said Hughes.
"He didn't train on Thursday and we will need to check him in the morning. I am reasonably confident that he will come through but we do have alternatives."
Hughes is also hopeful American right-back Geoff Cameron will shrug off the calf problem that kept him out of last week's draw with West Brom.
"Geoff has trained," said Hughes. "Hopefully he won't get a reaction."
Meanwhile, the Stoke boss has confirmed he is open to the idea of another American, Brek Shea, leaving the Britannia Stadium on loan.
Shea was signed from Houston Dynamo by former manager Tony Pulis in January but has failed to make an impact under Hughes.
That has led to the 23-year-old expressing concerns about his hopes of making Jurgen Klinsmann's World Cup squad.
"My priority is not to get him into the USA World Cup squad. I want to get him ready to play Premier League games here," said Hughes.
"We will look at the situation and if we feel an opportunity presents itself for Brek to go out on loan and play games at a decent club and it would benefit us, we will look at it."