Villarreal will be without Marcos Senna for this week's Champions League return meeting with Arsenal because of injury.
The Spain international midfielder limped out of Saturday night's 2-0 home defeat by Malaga in the 80th minute due to a hamstring problem, leaving the Yellow Submarine with 10 players as coach Manuel Pellegrini had already made three substitutions.
It is not yet known how long Senna will be out for but, according to Villarreal's website, he will definitely miss Wednesday's Champions League quarter-final second leg at the Emirates Stadium.
Senna scored Villarreal's goal as they drew the first leg with Arsenal 1-1 at El Madrigal last week.
His injury comes a week after team-mate and fellow Euro 2008 winner Santi Cazorla suffered a broken leg in the 3-0 loss at Almeria which will keep him out of action for around three months.
Aside from that, Pellegrini was also without Cani and Mati Fernandez for Saturday's match because of injuries.
A concerned Pellegrini said: "Obviously when you lose you are worried and must work hard to improve, but it's also true that the injuries have affected us and causing us problems.
"We lacked almost all of our creative line (against Malaga)," added the Chilean, who was also missing French forward Robert Pires through suspension.
"It was one of those days when the ball didn't want to go in for us, while Malaga took advantage of their first shot at goal.
"We could have played all day and the ball still wouldn't have gone in."
Despite that though, Pellegrini remained optimistic his side can still fulfil their objectives for the season, adding: "I still think that we have our chances and we are going to fight until the end."
