Fulham made an emphatic Europa League debut after Bobby Zamora inspired a 3-0 victory over FK Vetra in Vilnius.
Zamora, who has rejected a move to Hull this summer, scored the opener, won a penalty converted by Danny Murphy and set up the third for substitute Seol Ki-Hyeon.
Making their first appearance in Europe since 2002, Fulham are now excellently positioned to progress from the third qualifying round with the second leg staged at Craven Cottage next Thursday.
New manager Mark McGhee's reign at Aberdeen began with a stunning 5-1 defeat at home against Sigma Olomouc.
The signs looked ominous for the former Motherwell boss and his Dons charges when Michael Hubnik opened the scoring for the Czech side after 18 minutes, but Charlie Mulgrew equalised with a majestic free-kick five minutes later.
Lukas Bajer restored Sigma's lead after 63 minutes with an equally magnificent set-piece and Jakub Petr grabbed a third six minutes later.
Substitute Michal Ordos added a fourth in the final 10 minutes with a rasping drive before Tomas Horova rounded off the scoring in the dying stages.
Motherwell were also dealt a shattering blow as they lost 3-0 to hosts Steaua Bucharest.
The Steelmen were handed a place in the qualifying rounds thanks to their second place in the SPL's Fair Play League, after Scotland's impressive disciplinary record had secured the country an extra place in Europe.
But an own goal from Stephen Craigan was followed by further goals from Banel Nicolita and Bogdan Stancu, and Jim Gannon's visitors could not respond.
Declan O'Brien proved to be St Patrick's hero once again as Jeff Kenna's men pulled off a magnificent first-leg win over Krylya Sovetov.
O'Brien, on loan from Dundalk, had scored in both legs to sink Valletta in the previous round and stepped up again with a 71st-minute strike to set up St Pat's for their long trip to Russia next week.
But Derry City's hopes hang in the balance after the Candystripes fell to a 1-0 defeat against CSKA Sofia.
Kostadin Stoyanov scored the only goal of the game in the 75th minute to round off a long spell of pressure by the home side and give them a crucial advantage.
