SpVgg Neckarelz, the lowest ranked side in the competition, drew a plum tie against Bayern Munich in the first round of the DFB-Pokal on Saturday.
The sixth division side will be the first serious opponents for new Bayern coach Louis van Gaal this season when the fixture takes place on the weekend of August 1-2, one week before the start of the Bundesliga season.
Holders Werder Bremen start their defence of the trophy with a tricky trip to newly-promoted second division side Union Berlin while last year's beaten finalists Bayer Leverkusen head for Bavarian amateurs Babelsberg.
Other intriguing ties will see Eintracht Frankfurt travel to local rivals Kickers Offenbach, Bundesliga champions Wolfsburg play at third division side Wehen Wiesbaden and the financially endangered Kickers Emden earn a lucrative home fixture with Cologne.
Meanwhile, Hertha Berlin go to Munster and Hamburg should attract a large crowd in the Dusseldorf Arena against Fortuna Dusseldorf.
Another of the lowest ranked sides, SG Sonnenhof Grossasbach from the fifth division, will host Markus Babbel's Stuttgart.