Former Brighton boss Poyet has emerged as the new favourite to become the next Sunderland manager following significant backing at Sky Bet.
Roberto Di Matteo had been considered the most likely candidate to replace his compatriot Paolo Di Canio but has now drifted out to 9/1 to get the job.
A consistent run of bets on Poyet has seen him come in from 8/1 on Tuesday morning to his current price of 4/6, while Steve McClaren (9/1), Tony Pulis (10/1) and Gianfranco Zola (14/1) are considered alternative options.
The Uruguayan boss is out of work since leaving Brighton over the summer, although he is still embroiled in a legal battle over his sacking.
Di Canio was relieved of his duties at the Stadium of Light after the Black Cats collected a solitary point from their first five games, leaving them rooted to the foot of the Premier League table.
Sky Bet Football Trader Chris Spicer said: "We installed Di Matteo as the initial favourite and our punters seemed in agreement as he attracted the majority of the bets, but there has been a significant shift in where the money is going.
"While we've seen some interest in McClaren, Pulis and Zola, the majority of the stakes are going on Poyet."
Odds subject to change.