The Welsh club face the challenge of combining their Europa League campaign with their domestic duties this term, and the St Mary's encounter will be their seventh game in 20 days.
While results have been good in continental competition - Swansea are top of Group A with two wins from two - a difficult run of Premier League fixtures has seen them suffer three defeats from their first half a dozen games.
The Swans have yet to find the consistency of performance that helped propel them to a ninth-place finish and Capital One Cup success last season, but Dyer does not reckon that is down to manager Michael Laudrup tinkering with his team.
"It's not that hard because we all know the style and the philosophy of our play and our roles in it," he said.
"We are training with each other - we know how to slot in and we can gel quickly.
"Our style helps us do that. It helps that anyone can come into the side and help the team.
"But there's still competition and everyone who comes off the bench or comes into the side gives it their all because you have to be on top form or you may not get a look in."
The former Southampton winger also insists there is are no individual frustrations down to the need for players' workloads to be managed.
"It's not about you. You can't go into games wondering if you're starting or not because you're head can go down if you're not," he said.
"You just have to be prepared to help the team whichever way and every time. We're all team players first.
"I don't think we have had to change mentality much because the number of games we have means you have to be realistic that no-one is going to play every game because your legs will give up.
"We need rest, we need to be at our strongest every time and that's why the manager is making the changes from game to game."
Facing Saints takes Dyer back to where his career started. The winger came through the youth ranks at the south-coast club, but eventually left for south Wales in search of regular first-team football.
He has been a mainstay for Swansea ever since, and recently signed a new four-year contract at the Liberty Stadium.
But the 25-year-old admits it is always special to go back and face his former club.
He said: "It will be nice to go back to where I started my career. I was there as a young boy and there's a lot of good memories there for me. But all that aside it's going to be a tough game and we will have to be on top form.
"They are doing really well. They've signed some good players and made a lot of additions.
"They've gelled well and the manager seems to know what he wants from his players.
"He seems like a manager who wants his players to play good football, which always helps as a player when you're encouraged to be positive like that.
"They've a lot of quality there and they're going to be a strong team."