The Welsh side face Everton in the FA Cup fifth round on February 15 and a draw in that match would mean a replay and the prospect of five games in 10 days.
This would include home and away legs with Napoli in the Europa League and Premier League games away at Liverpool and at home against Crystal Palace.
Laudrup's concerns echo those of Fulham boss Rene Meulensteen, who rested a number of players for his side's FA Cup tie with Sheffield United on Sunday, just over 48 hours before their Premier League game against Laudrup's side.
"When you are playing two games in 48 hours, I can understand that. I agree with that," said Laudrup, whose side are 15th in the Premier League table, just three points above the bottom three.
"I saw Meulensteen's statements. If they have a game Tuesday, why should they play Sunday? This game against us should be on Wednesday, this is the only place in the world where you play two games in 48 hours.
"Elsewhere, you have 72 hours at least. If you play Saturday, the next game is Tuesday; if you play Sunday, it is Wednesday. So I understand that.
"We may have to do the same in February if we have an FA Cup replay. I heard it today, maybe we can change it but you have to finish the current round before the next round.
"The sixth round is on March 8 and in the midweek before there are international friendlies and the two midweeks before that are European games.
"But they knew that when they made the fixtures before the start of the season, that you could have teams playing in Europe who could have a replay.
"It does not help teams in Europe, it could happen for Chelsea and Manchester City.
"We all want Premier League teams to do well in Europe so I don't think it helps to play Thursday, Sunday, Tuesday, Thursday, Sunday. I am sorry I cannot really see how that helps."