The Swans sit 15th in the top-flight standings at present, but only six points separate them from the drop zone.
A 1-0 defeat at Hull City on Saturday has kept Garry Monk's side in trouble, with a frustrating campaign having failed to provide a spark.
They still have five fixtures in which to end any lingering relegation fears, but the first of those sees them play host to title-chasing Chelsea on Sunday - live on Sky Sports.
Dutch midfielder De Guzman acknowledges that the Swans need to start digging deep and believes it would be foolish of them to assume that they will get the results required to keep their head above water.
He said in the South Wales Evening Post: "We're not safe. After the win against Norwich, we wanted to build on that and get a good result at Hull.
"It's a big blow. It's a game we have to learn from and take the positives and negatives to work on for next week.
"Chelsea will not be easy. They are a great team. It's going to be as difficult as possible to get a win.
"I can't say that one more win will be enough. It's difficult.
"There are a lot of the bottom teams down there taking points. It's important not to look at the bottom teams, but to look at ourselves and getting the results we need.
"We can't assume that 36 points will do it. We've got to take every game as a final and try and get as many wins as we can."