Spurs are currently unbeaten in their last seven games and four straight Premier League wins has seen Andre Villas-Boas' side continue their Champions League push.
The North London club go into the game as underdogs but Vertonghen says he is relishing the prospect of taking on the Italian giants.
"This is why we play football," he said. "It's a tough week, a tough season, actually. We started the week well at West Ham and we needed the win against Arsenal. That was fantastic and now we prepare for Inter. No doubt it's a special time for the fans as well."
"I only arrived at the club six months ago but you can feel this is one of the most important games of the season.
"It's my first win in the North London derby, so I'm happy. We had a difficult 30 minutes but we stayed compact, stayed playing as a team and the goals were great for us.
"We said don't concede an early goal in the second half like at United, but we're a very strong team, we can play compact and we showed that again."