Spurs are due to take in fixtures in three different competitions over the course of six action-packed days.
They start at home to Tromso in the Europa League on Thursday, before travelling to Cardiff City in the Premier League on Sunday and Aston Villa in the Capital One Cup on Tuesday.
Villas-Boas feels such a gruelling run of games could seriously impact on his players, with it impossible for a settled XI to compete in an important run of games without a period of rest.
"After this game (against Tromso) we have not only the Sunday game but the Tuesday game, which I found as an incredible surprise," he said.
"How can the game be scheduled after two days? This is putting the players' career at risk and the risk of injuries.
"I can understand the reasons why our game against Aston Villa for the Capital One Cup was chosen to be on Tuesday, bearing in mind the other fixtures, but I find it absolutely incredible that we have to risk injuries to our players in a game we play on that Tuesday.
"This amount of fixtures forces us to make some changes in the team, but we take the competition very seriously and we will be very strong."