Spurs arrived home in the early hours of Friday morning after winning their Europa League clash with Anzhi Makhachkala 2-0 on the outskirts of Moscow.
First-half efforts from Jermain Defoe and Nacer Chadli proved the difference and Villas-Boas said: "Now it is just about recovery.
"Obviously the win helps us recover mentally, which helps us recover physically quicker. It is nothing different from what we've done in the past.
"We will try to get at least the minimum sleep, but from Friday to Saturday we will sleep well and recover the players for West Ham.
"We will just prepare for that game on the day of the game, give the players information on the day of the game."
The Portuguese will be unable to call on Younes Kaboul after the injury-plagued defender took a knock on Thursday night.
Etienne Capoue is also out, although Villas-Boas hopes he will return in 10 days, but the Spurs boss is more hopeful on injured trio Danny Rose, Aaron Lennon and Emmanuel Adebayor.
"Danny Rose is a 50-50 chance for West Ham," he added. "Definitely yes after the international break, but probably not ready for West Ham.
"Aaron was back training with the team on Monday. He will be regaining his fitness with the team and we look to have him back in contention for a first-team place after the international break.
"Ade has just come back to training with the first team. We travelled on Tuesday so we haven't trained with him.
"He definitely won't be involved against West Ham, so hopefully within this next international break we can build him up to start competing again for his place in the team."