The France international was knocked unconscious during last weekend's game against Everton at Goodison Park.
Lloris sustained the blow when he was stuck by Romelu Lukaku's knee during the 0-0 draw, and Spurs have been criticised by various organisations for allowing the keeper to play on for the remainder of the match.
Tottenham were criticised by FIFA's medical chief among others for the decision not to substitute Lloris, yet the club's medial staff said they were "totally satisfied that he was fit to continue playing".
The France captain was rested for Thursday's Europa League win over Sheriff Tiraspol, but manager Andre Villas-Boas claimed afterwards that he would return against Newcastle.
However, Lloris was not included in the squad to face the Magpies as Brad Friedel once again deputised, with Tottenham posting a statement from Wayne Diesel, head of medical services, explaining the absence.
"We've continued to monitor Hugo all week and after discussions, Andre and the medical department have agreed to afford the player a couple more days' rest," said Diesel.
"Hugo is naturally disappointed as he was keen to return to action however we feel this decision is in the player's best interest."
Speaking to Sky Sports ahead of Sunday's match, Villas-Boas said: "The medical department advised he still needed a couple more days so I would expect him to be back for the (World Cup) play-offs for France."