Spurs look set to miss out on UEFA Champions League qualification and speculation has suggested that Lloris could be a target for a host of clubs at the end of the season.
Sherwood admits it is no surprise to hear that Lloris is attracting interest, but has made it clear that it would take a bid of around £100million for chairman Daniel Levy to consider a sale.
Lloris has an opportunity to shine on the world stage with France this summer but Sherwood does not believe his performances at international level will make a difference and maintains, with two years remaining on his contract, that the former Lyon man will not be going anywhere.
"He is one of the best keepers around," said Sherwood. "Of course, people are going to want him. But I'm also sure the club won't be tempted to get rid of him.
"He is one of the top goalies and unless someone is going to spend £100million on him - and keepers do not get bought for that money - I don't think he will leave.
"It was only that kind of figure that tempted the club to sell Gareth Bale - and he desperately wanted to leave and progress his career at Real Madrid. He hasn't got to play a blinder for France at the World Cup because people already know what he can do. They know he is a fantastic goalie.
"Even if he was terrible for France, I don't think it would make a difference as to how people view him. Everyone can recognise it.
"He has never said to me or anyone else at the club that he wants to leave. And he does not perform like he wants to leave. He gives everything all the time and that is why he is a favourite of the players and fans."
Sherwood is also confident that Emmanuel Adebayor will stay at White Hart Lane in the next transfer window, having helped to revive the striker's career since taking charge.
"Adebayor is a pleasure to work with and is a good role model for younger players. He trains excellently, conducts himself well and I've never had a problem with him," said Sherwood.
"He has married his talent with a top attitude and has been reaping the rewards since I got here.
"I'm sure he wants to be part of the future here. I don't think he wants to keep moving clubs.
"His family is settled in London and he just wants to help us win as many games as possible."