It will be Pochettino’s first competitive home game in charge and Spurs will be favourites to defeat the side managed by their former boss Harry Redknapp.
QPR were promoted via the Championship play-offs and suffered a 1-0 defeat at home to Hull in their opening game of the season last weekend, while Tottenham won at West Ham.
But Pochettino said of QPR: “We watch a lot of games from them, and the last game they played well.
“But, in football, not always when you play well, you win. It is a derby, we expect a very, very tough game.
“I am looking forward to it, my first official game at White Hart Lane in front of our supporters.
"It is important to win, play well and develop our style and improve, which is important in each game, to try and improve.”
Forwards Roberto Soldado and Harry Kane were on target in the 2-1 midweek Europa League win at AEL Limassol, which pleased Pochettino.
"Always goals are important for Harry and for Roberto," he said. "The strikers always need to score.
"In the team, when the strikers score, all the people are happy."