Newcastle boss Alan Pardew is gearing up for a fight to hold on to skipper Fabricio Coloccini for the second time in five months.
Brian McDermott confirmed on Tuesday that the Royals had made an offer for Ince, who is high on Liverpool's wanted list.
The 20-year-old's performances for the Seasiders have earned him a host of admirers, with the youngster scoring 15 goals in 27 league appearances.
He has been linked with a return to boyhood club Liverpool in this month's transfer window but Reading entered the race for his signature.
It is believed that the Royals offered a fee in the region of £7million for a player who scored twice in Blackpool's win at Wolves on Saturday.
Reading have already struck three times in the transfer market this month, bringing in Daniel Carrico, Hope Akpan and Stephen Kelly as they bid to avoid relegation.
McDermott had told Sky Sports News: "He's a Blackpool player so it's difficult for me to talk about players that don't belong to us.
"He's got quality, he can play number 10 or out wide on either side, he loves his football and can score or create goals.
"He's got a real hunger. He's a good player with potential, I imagine there's a lot of interest in him. But once again I have to say this is a player who doesn't belong to us."