Championship side Rotherham have signed Manchester United defender Reece James on loan until January 10.
Brighton have completed the signing of Aston Villa striker Darren Bent on an initial month's loan.
Teenagers Crawford, 18, and Shankland, 17, and 22-year-old Sinclair will all travel to England on Monday and will stay until Thursday.
Ayr, who are a part-time club, confirmed that the trio would be due back by next Saturday ahead of their game at Brechin City.
Honest Men boss Mark Roberts told the Ayrshire Post: "We've also had clubs such as Bolton, Crystal Palace and Charlton at our games this season and it underlines that the Academy is doing a great job.
"Crawford and Sinclair are there on merit while Shankland is going due to his reputation since a boy.
"It's a great chance to train and learn. They are all aged under 23 so if anything comes from it, there could be good money for Ayr."