New Tranmere boss Micky Adams has bolstered the clubs attacking options with Cardiff's Danny Johnson on a one-month loan.
Full-back Maynor Figueroa has returned to Wigan on a one-month loan deal from Hull.
The 29-year-old France international, signed from Toulouse in 2009, played 25 games for Los Che last season, scoring twice.
Mathieu, while participating in the new season's kit launch, told valenciacf.com: "I am delighted to renew with Valencia, in this great club.
"I feel great and very happy to stay several more years in Valencia."