Southampton will not accept offers for forward Jay Rodriguez or midfielder Morgan Schneiderlin this summer.
Everton forward Kevin Mirallas has hinted that he will sign a new contract at Goodison Park in the summer.
The Spain U-21 international is yet to play in the Premier League for Spurs and he enjoyed a temporary spell with Almeria last season.
Falque played a role in helping the Andalusian side gain promotion to the Spanish top-flight, scoring twice in 22 appearances.
The 23-year-old also spent a brief spell on loan at Southampton in 2012 but will now return play in his home country.