Chelsea boss Jose Mourinho values Belgium playmaker Eden Hazard at £200m after reported interest from Real Madrid.
Alan Pardew is weighing up chasing a big-name summer signing to boost Crystal Palace's profile.
The 25-year-old was one of Orient's stand-out performers last season as they reached the League One play-off final before losing to Rotherham.
Omozusi was virtually an ever-present in Russell Slade's side, making 50 appearances for Orient and his performances have not gone unnoticed.
Orient took up an option on Omozusi's contract to extend it for a futher 12 months with his previous deal expiring this summer.
Reading are believed to be weighing up a move for Omozusi and are ready to test Orient's resolve to keep hold of the full-back.