A niggling knee problem has prevented the midfielder from competing for club and country as often as he would have liked in recent years.
Collison has spent regular spells on the sidelines since 2009, with a setback last summer keeping him out of West Ham's return to Premier League competition.
He has, however, been back in contention since December and is confident that he can put the struggles of the past behind him.
Ahead of his first outing for Wales in almost a year, against Austria on Wednesday, Collison said: "It's been great to be back out on the pitch because it's been a bit of a long time once again.
"It's been frustrating after playing almost the whole of last season and then watching the boys play in the Premier League week in, week out against the best teams.
"It's good to be back and I've had some good games since then. I'm looking to build on those now and prove myself again.
"To be honest, the knee feels better than it has done in about three years, which is obviously good."