Last season's top scorer Romelu Lukaku will return to Chelsea for pre-season, while Zoltan Gera, Marc-Antoine Fortune and Jerome Thomas are all out of contract.
And Steven Reid hinted this week he may also be on his way out of The Hawthorns after failing to make enough appearances to trigger an extension to his deal.
But Clarke's priority is continuity following last season's eighth-placed Premier League finish.
"I think my ideas on the squad are similar now to how they were as the season progressed," he told the Albion website. "I don't think we need radical reshaping of the squad.
"It's a squad that has finished in the top 11 of the Premier League for the last three seasons.
"There are three or four players that won't be here next season that need to be replaced and we have to replace them wisely - but that's normal."
Clarke led Albion to their highest finish in 1981 in his first season in charge, but the Scot's ambitions extend beyond that.
He said: "I've always been hungry, right from the start of my career. I've always been ambitious, I always want to be successful and I want to do better. That's what drives me on.
"I think the day I wake up and I don't want to be better than yesterday is the day I'll stop."