The 16-year-old has featured prominently for Barcelona in the early stages of the season, scoring against both Osasuna and Valencia.
Barcelona say they are managing the winger’s playing time carefully, to prevent early burnout.
Fati missed the 2-0 win over Getafe last weekend due to growing pains and is also set to be absent against Inter, reports Mundo Deportivo.
Barcelona have Lionel Messi and Ousmane Dembele back available after injuries.
Barcelona are aiming for their first Champions League win of the season after drawing 0-0 with Borussia Dortmund in their opening group game.