Kadeem Harris and Will Grigg are added to the Bees squad for the visit of the U’s.
Winger Harris has joined on loan from Cardiff and striker Grigg missed last weekend’s 2-1 defeat at Stevenage as he was on international duty with Northern Ireland.
Boss Uwe Rosler has no injury worries but plenty of selection dilemmas after three straight defeats.
Richard Lee could return in goal after David Button’s mistakes in the last two matches resulted in goals, defender Martin Taylor was hauled off at Stevenage five minutes into the second half and Marcello Trotta’s place in attack will also be under threat.
Colchester are unlikely to be able to welcome back any of their injured players for the trip to Brentford.
Defender Ryan Dickson is closing in on his return after illness but still needs another week of training under his belt before being back in contention.
Defender Josh Thompson was this week told he must undergo ankle surgery, ruling him out for another three months, while winger Drey Wright is already recovering from a knee operation.
Sanchez Watt (thigh), Mark Cousins (foot), Tom Eastman (ankle) and Mason Spence (hamstring) are also set to remain on the sidelines.