Nicky Forster takes charge of Brentford for the first time following manager Andy Scott’s departure on Thursday.
The veteran striker’s first decision will be whether to pick himself after he was an unused substitute in Scott’s final game, Tuesday night’s 4-1 defeat at Dagenham.
Goalkeeper Richard Lee returns from a one-match ban following his red card against Yeovil last weekend and will take over from player-coach Simon Royce.
Sam Saunders came on as a substitute against the Daggers after a hamstring problem so fellow winger Sam Wood is the only injury absentee as he continues his recovery from a broken arm.
Forster could include full-back Michael Spillane and midfielder Marcus Bean, who were both left out of Scott’s last squad.
Argyle are hoping to welcome Joe Mason back into the fold for the clash in west London.
The 19-year-old has missed Argyle’s past three games with an ankle injury but is set to return should he come through a training session on Friday.
Speaking about Mason’s impending return, Pilgrims coach Adam Sadler said: “Everybody connected to the club – players, fans, staff – all know the talent and the ability of Joe.
“He’s a real handful, has got loads of potential and will grow into a fantastic footballer, so it gives everybody a lift to see someone of Joe’s quality come back into the reckoning.”
Argyle manager Peter Reid has no new injury concerns to contend with following Tuesday’s 1-0 defeat at Yeovil, although Onismor Bhasera (knee) and Jim Paterson (personal reasons) remain sidelined.
Yala Bolaise will also miss the Griffin Park encounter after picking up a late red card at Huish Park.