Bristol Rovers manager Dave Penney could hand debuts to Gavin Williams and Jean-Paul Kalala in the home clash with MK Dons.
Midfielders Williams and Kalala, both deadline day signings from Bristol City and Yeovil respectively, are hoping to play some part.
Williams is on loan until the end of the season, while Kalala has signed a short-term deal until June 30.
Penney may also play Peterborough forward Rene Howe and Reading midfielder Scott Davies after the pair joined the npower League One side on loan last week.
Rovers have no fresh injury concerns, but are blighted by suspension to two key players, with midfielder Chris Lines and defender Danny Coles both missing out.
Promising youngster Keanu Marsh-Brown could make his professional debut in MK Dons’ trip to Bristol Rovers.
The 18-year-old England youth international recently signed a new two-year contract with parent club Fulham, although he has yet to make his first-team debut.
And after penning a one-month loan deal with Dons on Monday, Marsh-Brown could make his bow in the League One clash at the Memorial Stadium.
French goalkeeper Willy Gueret, however, will not feature as he is poised to join Kettering after his Dons contract was cancelled by mutual consent.
Gueret was first-choice goalkeeper and a regular starter last season but has failed to appear for the first team this time around following the arrival of David Martin from Liverpool last July.
Midfielder Mark Carrington also plays no part having left Dons by mutual consent on Tuesday, subsequently agreeing a deal to join Scottish Premier League club Hamilton as a free agent.