Veteran goalkeeper Kevin Poole will play for Burton against Rotherham in the Johnstone’s Paint Trophy.
The Football League’s oldest player, 47, will replace Adam Legzdins who has dislocated a finger.
Poole, goalkeeping coach at the Pirelli Stadium, made six appearances for the Brewers in League Two last season but this will be his first game of this campaign.
Keith Gilroy could also be given his first start of the season. The winger, who has had a hamstring problem, came off the bench for his first outing of the campaign during the home league win over Stockport on Saturday.
Manager Paul Peschisolido could opt to rest striker Shaun Harrad, while youngsters Garyn Preen and Jack Dyer will be hoping for a chance to impress the Canadian.
Rotherham manager Ronnie Moore is set to ring the changes for the trip to face the Brewers.
Moore, whose side sit third in League Two, could give a chance to several of his squad players for the Pirelli Stadium clash.
Goalkeeper Jamie Annerson is in line for a rare start, while Dean Holden could be handed a starting role at right-back after featuring on the bench in recent weeks.
Tom Elliott returned to the squad after a hamstring injury for the 1-1 draw with Bury at the weekend and he will be hoping for a start along with fit-again Ryan Taylor.
Tom Pope is struggling with a calf injury, but hopes to be involved and skipper Ryan Cresswell should return to the fold after missing the Gigg Lane clash following the death of his grandfather.
The Millers, who beat Lincoln 1-0 in the first round, face the Brewers for the second time this season after a blowing a three-goal half-time lead in their 3-3 League Two draw last month.
Kick-off for the match is at 7:30pm.