Carlisle will assess James Berrett ahead of the clash.
The Cumbrians expect Berrett to be fit after he was substituted after a knock to the head during the weekend’s 2-0 defeat against MK Dons.
Berrett suffered from double vision after the game but manager Greg Abbott is confident that the midfielder would be fine in time for the game.
Paul Thirlwell is ready to deputise if Berrett is allowed longer to recover.
Michael O’Halloran is in line for his full debut, while fellow loanee Jake Jervis is eligible to play in this competition after being unavailable in the Capital One Cup.
Danny Livesey will be sidelined for a further two weeks with a hamstring injury, while Lee Miller (ankle) and Rory Loy (broken leg) are not near a return.
Preston manager Graham Westley has no new injury concerns.
The clash with the Cumbrians is North End’s second game in 48 hours following their 4-1 victory against Swindon on Sunday.
With the quick turnaround, Westley may opt to make changes to his starting XI, but having recorded back-to-back 4-1 wins, his team will be full of confidence and eager to play.
David Amoo, Andy Procter and Chris Beardsley all came off the bench to feature against the Robins and will be first in line should Westley choose to rotate.
Skipper John Mousinho remains doubtful with a thigh injury, while midfielder Joel Byrom is close to a return from a thigh strain.
Lee Holmes (gashed leg) and Lee Trundle (knee) are long-term absentees.