Ole Gunnar Solskjaer’s haven’t lifted the trophy since 2013 – Sir Alex Ferguson’s final year at Old Trafford.
The Red Devils already trail leaders Liverpool by 12 points this campaign.
Berbatov told Betfair : “It is frustrating and difficult for me to admit that United are so far behind Manchester City and Liverpool.
“When it comes to playing the game, you can see how confident and calm on the ball they both are, they know how to play and sometimes United don’t have that and they suffer because of that.
“I hope that Manchester United don’t end up like Liverpool and wait at least 29 years for the title. Six years is a long time to wait to win a title for a team like Manchester United.
“When you get into that spiral you are going to start slowly losing your DNA, look at Liverpool and all those years, you don’t want that.
“Sure, Liverpool are playing better now, but it has taken them so long to get to this point now where they are playing great football.
“United need to find that winning formula as soon as possible.”