Max Gradel will miss six months after suffering a ruptured cruciate knee ligament, while Tyrone Mings could face time on the sidelines for Bournemouth.
The Cherries’ summer signing from St-Etienne was injured during Saturday’s 1-1 home draw with Leicester and will now have surgery to repair the damage.
There could yet be further fallout from the Leicester game as Bournemouth await further news on a knee injury sustained by record signing Tyrone Mings.
The defender has damaged medial ligaments and needs further assessment before a timescale can be put on his recovery.
Mings was injured after appearing as a half-time substitute for left-back Charlie Daniels, who could miss as many as four weeks with a muscle problem.
The injuries partly explain a busy deadline day for Bournemouth, who signed striker Glenn Murray from Crystal Palace and secured loan deals for Aston Villa left-back Joe Bennett and River Plate midfielder Tomas Andrade.