There was little to cheer from either side in a disappointing first-half, though Wycombe were left wondering how they didn’t score after seven minutes.
Following a right-wing corner, Mike Williamson’s header was blocked, as was Chris Zebroski’s follow-up shot, and then Williamson’s second effort went wide.
Two minutes later Matt Harrold had a shot well saved by Andy Warrington in the Rotherham goal.
Rotherham lost leading marksman Reuben Reid to injury after 22 minutes and their only goal-worthy effort was a snap-shot by debutant Omar Garcia, from Dale Tonge’s cross, which whistled just over the bar.
There was little improvement after the break though only a brilliant save by visiting goalkeeper Scott Shearer after 50 minutes kept out Micky Cummins’ goalbound header.