The former United midfielder favours a 3-5-2 formation, with Marcus Rashford and Anthony Martial up front.
In midfield, Pogba and January signing Bruno Fernandes sit ahead of Nemanja Matic.
Which means youth product Scott McTominay and resurgent midfielder Fred miss out.
Aaron Wan-Bissaka and Brandon Williams line up in the wing-back positions for Hargreaves, with Luke Shaw at left centre-back – a role he has impressed in of late – alongside Harry Maguire and Victor Lindelof.
“It’s a difficult one because obviously you’ve got to build around Bruno,” Hargreaves said on The Analysis Show.
“And I think if Bruno’s in there you can only have one sitter.
“So that could easily be Pogba and that could be Bruno Fernandes but [Matic] needs to always sit.
“In the end I think you’ve got to build around your best players and your best players are Bruno Fernandes and Paul Pogba.
“So you get them in the team and that means rather than these guys getting box to box, Fred and Matic, you just need a sitter.
“The reason Man United are so far behind Man City, defensively the goals conceded are almost the same, the big difference is in terms of goals scored.
“I think they’re 20-plus behind Man City. If you can get Pogba into your side with Bruno Fernandes, with Rashford and Martial, then all of a sudden that attack is very, very good.
“You’ve got one of the best goalkeepers in the division, De Gea, one of the best defences in the Premier League outside of Liverpool and Sheffield United.
“So that’s not an issue, can you address issues further up the pitch?
“I think if you get a sitter plus Fernandes, Pogba, Rashford and Martial, that’s a great attacking line up.”