Hughes has a decision to make over whether to start striker Ryan Christie after his midweek exertions with the Scotland U21team in Switzerland.
Caley Thistle skipper Richie Foran has made improved progress in his bid to overcome a knee injury after having fluid removed from around the joint.
But the Irish forward will not be available for action in the coming weeks.
Motherwell have a host of selection problems for their Scottish Premiership clash at the Tulloch Caledonian Stadium.
Craig Moore has suffered a setback regarding his return to first-team action from cruciate ligament damage.
The Motherwell forward has now gone down with illness and will remain on the sidelines along with defender Steven Hammell and midfielder Jack Leitch
Caretaker-boss Kenny Black will also be without front man Bob McHugh, as well as midfielder Stuart Carswell and Paul Lawson, who have suffered knocks in reserve games.