Top scorer Murphy, who missed a late penalty in Wednesday’s 2-1 defeat at Leeds, and Sears were dropped to the bench at Elland Road as Town lost for a second successive game.
But boss Mick McCarthy has confirmed both will start with Luke Varney and on-loan Chris Wood likely to make way.
Teddy Bishop (ankle) could be involved, Noel Hunt (knee) is out for the rest of the season, David McGoldrick (hip) and Luke Hyam (knee) are not ready to return and Darren Ambrose and Stephen Hunt (both hamstring) continue to be assessed.
Brentford, one point and one place above Ipswich in sixth, are hoping to add Alan Judge to their squad.
The midfielder, who recently returned to fitness after a knee injury, missed Tuesday night’s 4-1 win over Huddersfield to have an injection in order to ensure he is ready for the weekend.
Boss Mark Warburton has a selection dilemma in attack after resting Andre Gray in midweek and seeing his replacement, Everton loanee Chris Long, score twice on his full debut.
January signing Lewis Macleod is still doubtful with a hamstring injury and striker Scott Hogan remains sidelined with cruciate ligament damage.
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