The German’s side are six points clear of Pep Guardiola’s City and could extend that margin to nine points with victory at home on Sunday.
City haven’t won at Anfield since 2003 and Guardiola has lost three of his four trips to the red half of Merseyside.
Klopp acknowledged the importance of the game but played down talk of it being a title-decider, so early in the season.
He said: “In the last 2 years each game we play is the most decisive. Not one where anyone says ‘we can lose that’. Trying to win titles and get to finals again, nothing changes. Cannot make games bigger than they are, Important game.”
“It’s a big game. Two really good teams. Good news it is at Anfield, that is cool. Floodlights. Big game. We will see, everything is on a plate, so nobody hides. We cannot only be offensive but if we are not brave v Man City we have no chance. We have to create.”
“Our positioning must be perfect all the things again. We really try to adapt to what the opponent is doing and make sure they cannot. It can lead to other things. Interesting football game.”
“It’s possible it could be 0-0 like last year, even with all these things. Depending on the formation, maybe you can’t be as creative or offensive (as normal). It will be an interesting football game.”
Klopp insisted the improvements Liverpool have made when facing City in recent times are “obvious”.
He added: “Last three games with City, a pen pretty late but 0-0, 2-1 at the Etihad, 11mm or whatever the ball wasn’t in and last one was a draw in Community Shield. We lost on pens. Good moments, we had the best part in 2nd half. They are important parts of our development.”
“If you want to climb you have to take top spot where City is. For us, it is obvious the improvements the boys have made [against them]. We have to play our best game, everyone. The guys who sell the hotdogs have to! That’s what I wish for.”