Both Mohamed Salah and Andy Robertson withdrew from their respective matches with Egypt and Scotland due to ankle injuries, and Klopp is hoping the rest of his squad return healthy.
Salah has reportedly aggravated a problem he initially sustained against Leicester last month he could be a doubt for the trip to Crystal Palace when the Premier League resumes.
Robertson revealed he has not trained properly for a fortnight but is hopeful a two-week break will allow him some much-needed recovery time.
“Now the boys go for the last international break of the year. They have to come back healthy. You saw it how intense it was [against City],” Klopp said.
“Hopefully they all come back healthy and then we go to Crystal Palace.
“I think the last games are somewhere on the planet on Tuesday in the week that we play on Saturday against Crystal Palace.
“So they will fly back on the Wednesday, Thursday have a recovery session and Friday, Saturday ‘Hello, Crystal Palace’.
“That’s the situation so nothing happens so far but it’s still the best situation we could have asked for so let’s hope we can carry on.”