Frampton went off in Saturday’s 1-1 FA Cup draw with non-league Staines after having his hand stamped on and if the scans reveal no fracture, the defender could start at the Den.
Danny Schofield was named on the bench at the weekend as he was struggling with flu in the build-up to the game, but he has now fully recovered and could earn a starting berth.
James Henry, who was ineligible for the clash against the Blue Square South side, has been struggling with a hamstring problem and only has an outside chance of making the game.
Jackett has a host of other injuries to deal with, with Neil Harris (back), Gary Alexander (heel), Tony Craig (cheekbone), Zak Whitbread (hip), Scott Barron (ankle) and Pat O’Connor (cruciate) all crowding out the treatment room.
The Lions, who have not won in three league outings, will go level on points with the Dons if they can pick up a win.