The South African star, who signed for the Hammers on the last day of the January transfer window, has been out with a knee problem since the 2-1 defeat at Burnley on February 10.
England midfielder Kieron Dyer and defender Danny Gabbidon (both hamstring) are not yet fully fit.
Herita Ilunga is set to miss out with a tendon injury while Luis Boa Morte (knee), Calum Davenport (leg) and Zavon Hines (knee) are all long-term absentees.
Kick-off at Old Trafford is 8pm.
Hammers (from): Green, Stech, Spector, Faubert, Tomkins, Da Costa, Daprela, Parker, Behrami, Kovac, Collison, Diamanti, Stanislas, Cole, Mido, Ilan, Franco.