Fryatt has been struggling with an Achilles problem and Freedman has confirmed he cannot play two games in four days. If the striker misses out, he could be in contention for Saturday’s game at Norwich.
Goalkeeper Dorus De Vries missed the goalless draw at Leeds due to a back spasm, but is expected to return to the squad.
On-loan Swansea forward Modou Barrow is available to make his debut after receiving international clearance.
Rotherham will have midfielder Lee Frecklington back following a one-game ban and he is likely to go straight into the side.
Boss Steve Evans must decide whether to recall fit-again skipper Craig Morgan or stick with on-loan Derby youngster Farrend Rawson in central defence.
Attacker Danny Ward has stepped up his training following a foot injury and will be in the matchday squad.
Matt Derbyshire is likely to lead the line against his former club as the Millers chase a first win at the City Ground since 1955.