Nuno Espirito Santo’s side host Braga in their opening Group K fixture at Molineux on Thursday still winless in the top flight.
But Neves has come out fighting and insisted, after six qualifying games which started in July, the Europa League has no bearing on their domestic form.
The 22-year-old said: “Fatigue doesn’t have anything to do with it, we’re all top players and are used to it. The Europa League doesn’t have anything to do with our position in the Premier League.
“It’s been a beautiful journey into the Europa League and it’s a historic moment for Wolves, we’re going to do our best.
“It hasn’t been an easy start to the season – we’ve had extra Europa League qualifying games and the Premier League is the best league in the world.
“You are always going to have these moments in the season and we need to return to winning ways as soon as possible.
“We have these games ahead of us and the most important thing is the game tomorrow.
“Our objective is to win the game. It’ll be difficult but we’re going game-by-game.”