The Reds signed Akpom on loan from Arsenal during the international break and the teenage striker will make his debut on Friday, possibly as a starter.
Dexter Blackstock came off injured at Norwich two weeks ago but he is fit again. However, Matty Fryatt continues to struggle with an Achilles problem and he will remain out.
Jack Hobbs has missed the last eight games with a hamstring injury but the central defender should be back in contention on Friday.
Wolves could recall Carl Ikeme if the goalkeeper shows no reaction to his return to full training.
The goalkeeper has been kicking this week after breaking his foot in February and could replace deputy Tomasz Kuszczak at the City Ground.
Wolves’ internationals have returned without any problems while Kevin Doyle remains available before moving to Colorado Rapids in the summer.
Tommy Rowe is out after a minor setback in his recovery from a broken foot after receiving a kick on the ankle.