The on-loan Watford midfielder was cautioned in the 2-1 win over Southampton and will now serve a two-game ban.
The U’s will also be without on-loan Ipswich striker Kevin Lisbie, who is cup-tied and is set to return to Portman Road, although he has indicated a willingness to stay with Colchester.
Steven Gillespie will continue up front at Deepdale on Saturday after playing 80 minutes of Monday’s win and is set for his third start of the season following hamstring trouble.
Kayode Odejayi will return to the line-up following his permanent switch to the Community Stadium on January 1.
Scott Vernon (knee), Lee Beevers (shoulder) and Ashley Vincent (ankle) remain sidelined.