Michael Duberry has been ruled out with a neck injury. The 36-year-old defender has a prolapsed disc and is due to undergo surgery after two injections failed to resolve the problem.
Duberry stays on the injury list with fellow absentees Andy Whing, Peter Leven and Liam Davis who all remain sidelined.
The game may also come too soon for Harry Worley, who is recovering from an ankle injury.
Manager Chris Wilder told the Oxford Mail: “I would’ve loved to have had the players back, there’s no doubt about that.
“If you took four senior players out of Manchester City or a club at our level they would say it hurts you.”
Bournemouth’s injury list is causing manager Lee Bradbury problems. Long-term absentees Wes Fogden, Stephen Purches,and Charlie Sheringham have been joined by Steve Fletcher (dead leg) and Mark Molesley (groin) on the sidelines.
Josh McQuoid is also unavailable with a foot injury which will keep him out of the side for two to three weeks, while Frank Demouge faces a longer lay-off with a knee problem.
Adam Bartlett (hamstring) and Tommy Elphick (Achilles) will try to prove their fitness but Richard Hughes is not match fit.
Eunan O’Kane will also not feature as he is on international duty with Republic of Ireland’s under-21s.
Bradbury will also have to decide on his first-choice goalkeeper after Shwan Jalal returned from surgery on a herniated disc to challenge Darryl Flahavan for a starting place.